MP-453086-5 QUALITY OF LIFE AFTER SHOCKS OR COMPLICATIONS IS SIMILAR BETWEEN SUBCUTANEOUS AND TRANSVENOUS DEFIBRILLATOR THERAPY

The PRAETORIAN trial showed that the subcutaneous implantable cardioverter defibrillator (S-ICD) is noninferior to transvenous ICD (TV-ICD) with respect device-related complications and inappropriate shocks in a conventional population. Nevertheless, type of underlying mechanism for differ between devices. Earlier studies have reported decrease quality life (QoL) patients or complications. It unknown if there difference QoL devices general, whether are associated same burden both arms. This prespecified analysis compares impact S-ICD TV-ICD on investigates cause device-specific reduction QoL. In trial, 849 were randomized (n=426) (n=423) therapy. was prospectively measured at baseline, discharge 12 30 months after implant, by measuring cardiac-specific physical functioning Duke Activity Status Index (DASI) psychological well-being 36-Item Short Form Health Survey (SF-36, divided 8 subscales). Patients who completed questionnaires baseline included this analysis. At each time point mean change score from calculated. without shock device related complication requiring intervention before their month compared. Regression models Wilcoxon rank sum tests used compare groups. A total 823/849 baseline. Questionnaires also majority these (92%), (85%) (69%). There no arms any (figure). months, significantly lower DASI (p=0.005) SF-36 subscales bodily pain (p=0.04), vitality (p=0.006) role specific – emotional (p=0.03). not different differences treatment first implant. but did These results confirm an acceptable alternative TV-ICD.